Host-defence peptides from the glandular secretions of amphibians: structure and activity.
نویسندگان
چکیده
This review covers the literature on the subject of biologically active peptides from the glands of amphibians. These include neuropeptides, antimicrobial and anticancer active peptides, antiviral agents, fungicides and peptides which complex with Ca calmodulin. Other topics covered include sex pheromones from amphibians, and the use of peptide profiling to differentiate between species and different populations of the same species.
منابع مشابه
معرفی پپتید ضدمیکروبی جدید با نام Buforin–K از ترشحات پوستی وزغ کویری بومی یزد
Introduction: Today, research in the field of antimicrobial peptides is active. Thus, the aim of this study is to purify and determine biochemical properties (especially antimicrobial effect) of new antimicrobial peptides from skin secretions of bufo kavirensis. Methods: This is a descriptive study. The skin secretions of bufo was purified by biochemical manners and antimicrobial effects was ...
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Amphibians have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. A novel peptide with antibacterial effects and without hemolytic activity was purified from skin secretions of Rana ridibunda by multisteps cation-exchange FPLC, revers...
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Host defense peptides are a vital component of the innate immune systems of humans, other mammals, amphibians, and arthropods. The related cationic antimicrobial peptides are also produced by many species of bacteria and function as part of the antimicrobial arsenal to help the producing organism reduce competition for resources from sensitive species. The antimicrobial activities of many of th...
متن کاملThe ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei.
The tailed frog Ascaphus truei occupies a unique position in phylogeny as the most primitive extant anuran and is regarded as the sister taxon to the clade of all other living frogs. Eight structurally related peptides, termed ascaphins 1-8, were isolated from norepinephrine-stimulated skin secretions of A. truei and were shown to possess differential growth inhibitory activity against Escheric...
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Recently a number of endogenous host defence molecules with antimicrobial activity have been identified in mammals, invertebrates and amphibians (for reviews see Ganz, Selsted Within this group of anti-microbial agents there are several small peptides (2-4K.) that include the defensins (found predominantly in mammalian phago-cytes), cecropins, diptericins, attacins, apidae-cins, abaecin, royali...
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عنوان ژورنال:
- Natural product reports
دوره 23 3 شماره
صفحات -
تاریخ انتشار 2006